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Historical timeline of breakthrough clinical trials for heart failure... |  Download Scientific Diagram
Historical timeline of breakthrough clinical trials for heart failure... | Download Scientific Diagram

Sacubitril/Valsartan and Sudden Cardiac Death According to Implantable  Cardioverter-Defibrillator Use and Heart Failure Cause: A PARADIGM-HF  Analysis | JACC: Heart Failure
Sacubitril/Valsartan and Sudden Cardiac Death According to Implantable Cardioverter-Defibrillator Use and Heart Failure Cause: A PARADIGM-HF Analysis | JACC: Heart Failure

Critical Questions about PARADIGM-HF and the Future
Critical Questions about PARADIGM-HF and the Future

Sacubitril/Valsartan: Neprilysin Inhibition 5 Years After PARADIGM-HF -  ScienceDirect
Sacubitril/Valsartan: Neprilysin Inhibition 5 Years After PARADIGM-HF - ScienceDirect

KoreaMed Synapse
KoreaMed Synapse

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure | NEJM
Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure | NEJM

Emerging Mechanisms in the Management of Heart Failure With Reduced  Ejection Fraction
Emerging Mechanisms in the Management of Heart Failure With Reduced Ejection Fraction

Clinical Trial and Biomarker Data | ENTRESTO® (sacubitril/valsartan) | HCP
Clinical Trial and Biomarker Data | ENTRESTO® (sacubitril/valsartan) | HCP

Frontiers | Sacubitril/Valsartan as a Therapeutic Tool Across the Range of Heart  Failure Phenotypes and Ejection Fraction Spectrum
Frontiers | Sacubitril/Valsartan as a Therapeutic Tool Across the Range of Heart Failure Phenotypes and Ejection Fraction Spectrum

Effect of neprilysin inhibition on renal function in patients with type 2  diabetes and chronic heart failure who are receiving target doses of  inhibitors of the renin-angiotensin system: a secondary analysis of
Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of

Effect of sacubitril/valsartan vs. enalapril on changes in heart failure  therapies over time: the PARADIGM‐HF trial - Bhatt - 2021 - European  Journal of Heart Failure - Wiley Online Library
Effect of sacubitril/valsartan vs. enalapril on changes in heart failure therapies over time: the PARADIGM‐HF trial - Bhatt - 2021 - European Journal of Heart Failure - Wiley Online Library

Novartis PARAGON-HF trial suggests Entresto® benefit in HFpEF patients but  narrowly misses primary endpoint | Novartis
Novartis PARAGON-HF trial suggests Entresto® benefit in HFpEF patients but narrowly misses primary endpoint | Novartis

Real-world effectiveness and safety of sacubitril/valsartan in heart failure:  A systematic review - International Journal of Cardiology
Real-world effectiveness and safety of sacubitril/valsartan in heart failure: A systematic review - International Journal of Cardiology

Clinical Trial and Biomarker Data | ENTRESTO® (sacubitril/valsartan) | HCP
Clinical Trial and Biomarker Data | ENTRESTO® (sacubitril/valsartan) | HCP

Trial Scorecard: PARADIGM-HF
Trial Scorecard: PARADIGM-HF

Effect of sacubitril/valsartan versus enalapril on glycaemic control in  patients with heart failure and diabetes: a post-hoc analysis from the  PARADIGM-HF trial - The Lancet Diabetes & Endocrinology
Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial - The Lancet Diabetes & Endocrinology

Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart  Failure | Circulation
Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure | Circulation

Use of Sacubitril/Valsartan in Heart Failure
Use of Sacubitril/Valsartan in Heart Failure

Promising New Therapies in Heart Failure: Ivabradine and the Neprilysin  Inhibitors | USC Journal
Promising New Therapies in Heart Failure: Ivabradine and the Neprilysin Inhibitors | USC Journal

PARADIGM-HF Trial design: Participants with NYHA class II-IV and LVEF ≤40%  were randomized to LCZ mg twice daily (n = 4,187) vs. enalapril 10 mg. -  ppt download
PARADIGM-HF Trial design: Participants with NYHA class II-IV and LVEF ≤40% were randomized to LCZ mg twice daily (n = 4,187) vs. enalapril 10 mg. - ppt download

Entresto Use in Heart Failure w Preserved Function – The Early Career Voice
Entresto Use in Heart Failure w Preserved Function – The Early Career Voice

Differential Impact of Heart Failure With Reduced Ejection Fraction on Men  and Women - ScienceDirect
Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women - ScienceDirect

Understanding the early mortality benefit observed in the PARADIGM-HF | VHRM
Understanding the early mortality benefit observed in the PARADIGM-HF | VHRM

PARADISE MI Trial: Is Sacubitril/valsartan (Entresto) useful in patients  with acute MI? – Visualmed
PARADISE MI Trial: Is Sacubitril/valsartan (Entresto) useful in patients with acute MI? – Visualmed

Entrestro for HFrEF: Are there any controversies?
Entrestro for HFrEF: Are there any controversies?

PARADIGM-HF and PARAGON-HF: Redefining HFrEF and HFpEF - PACE-CME
PARADIGM-HF and PARAGON-HF: Redefining HFrEF and HFpEF - PACE-CME

The PARADIGM-HF trial (reproduced with permission from Wolters Kluwer). 6 |  Download Table
The PARADIGM-HF trial (reproduced with permission from Wolters Kluwer). 6 | Download Table